Epstein–Barr virus encoded LMP1 downregulates TCL1 oncogene through miR-29b
نویسندگان
چکیده
منابع مشابه
miR-29b
Multiple myeloma (MM) is a heterogeneous disease originating from the transformation of a post-germinal center B cell. MM pathogenesis is a multistep process with chro-mosomal changes, genetic and epigenetic events occurring at different stages during the course of the disease. 1 MicroRNAs (miRNAs) are well known to be transcriptional repressors, possessing tumor suppressor (Ts) or oncogenic fu...
متن کاملNutlin-3 downregulates the expression of the oncogene TCL1 in primary B chronic lymphocytic leukemic cells.
PURPOSE The oncogene TCL1 plays a key role in the development of B chronic lymphocytic leukemia (B-CLL), but it is not known whether TCL1 could be modulated by therapeutic approaches. EXPERIMENTAL DESIGN B-CLL patient samples (n = 35) and B leukemic cell lines (EHEB, JVM2, JVM3, MEC1, MEC2, and BJAB) with different p53 status were exposed to Nutlin-3, a small-molecule inhibitor of the p53-MDM...
متن کاملSelection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from Southeast Asia.
The geographically constrained distribution of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) in southeast Asian populations suggests that both viral and host genetics may influence disease risk. Although susceptibility loci have been mapped within the human genome, the role of viral genetics in the focal distribution of NPC remains an enigma. Here we report a molecular phyl...
متن کاملEpstein-Barr virus-encoded LMP1 increases miR-155 expression, which promotes radioresistance of nasopharyngeal carcinoma via suppressing UBQLN1.
OBJECTIVE Epstein-Barr virus (EBV)-encoded latent membrane protein (LMP1) can drive aberrant expression of miR-155 in nasopharyngeal carcinoma (NPC). In this study, we investigated the regulation of miR-155 expression over UBQLN1 and studied their effects on radio-sensitivity of NPC. MATERIALS AND METHODS MiR-155, LMP1 and ubiquilin-1 expression were measured in 40 cases of NPC cases. The reg...
متن کاملCancer Therapy: Preclinical Nutlin-3 Downregulates the Expression of the Oncogene TCL1 in Primary B Chronic Lymphocytic Leukemic Cells
Purpose: The oncogene TCL1 plays a key role in the development of B chronic lymphocytic leukemia (B-CLL), but it is not known whether TCL1 could be modulated by therapeutic approaches. Experimental Design: B-CLL patient samples (n 1⁄4 35) and B leukemic cell lines (EHEB, JVM2, JVM3, MEC1, MEC2, and BJAB) with different p53 status were exposed to Nutlin-3, a small-molecule inhibitor of the p53–M...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncogene
سال: 2009
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2009.439